The Police Bus is owned by the Empire Bay Police Department, who use it to transport prisoners to and from Hartmann Federal Penitentiary. It's a variant of the Parry Bus painted blue and white with police vehicle markings and steel bars on the windows.
- In the base Mafia II game the bus is seen transporting Vito to prison in Chapter 6 and again briefly in the opening of Chapter 7 as it drops him off at the bus station.
- In Jimmy's Vendetta you steal one in the mission Police Bus Theft.
- Like the Parry Bus, it's based on the GM "old-look" transit bus.
- In Jimmy's Vendetta the bus is referred to as Parry Bus Prison.
- Other than in Police Bus Theft, the only way to drive one is through game modification.