New Bordeaux's status as a major port for the Southeast United States has made it one of the most important waypoints for smuggling between the U.S., the Caribbean, and Latin America. Under Sal, nothing got into or out of the city without his say-so. Sal successfully blocked potential rivals from gaining a foothold in the city's other criminal operations, installing his brothers in the major rackets while putting loyal and well paid lieutenants in charge of secondary ones. With his capos and lieutenants in control of all major districts in the city, Marcano allowed the poorer districts to be run by local groups, like the Black and Irish mobs, in exchange for a hefty cut of the profits, thus controlling every criminal operation in the city.
In February 1968 Sal Marcano plans a robbery of the Federal Reserve, taking over 6 million in cash and, more importantly, money plates for his counterfeiting operation. Afterward Sal double-crosses his accomplices and keeps all the cash for himself, killing Sammy Robinson, his son Ellis, Danny Burke, and leaving Lincoln Clay for dead.
Clay survives the attack, and with the help of John Donovan, the two devise a plan to take down Marcano and his entire operation. Over the summer and fall of 1968, and with the help of Clay's underbosses, the two do just that. District by district, Clay takes over the city, decreasing Marcano's resources and draining the cash he needs to get his casino up and running. Before long all of Sal's rackets and districts are gone, leaving him with nothing but his failed casino, son Giorgi, and a handful of men. Holed up at the half finished casino, Sal and Giorgi make their final stand against Clay, which fails.