Don Salieri is the boss and founder of the Salieri Crime Family. He first arrived in the United States in 1908 and was originally a caporegime under Don Peppone along with Morello. Initially, both Salieri and Morello respected and valued each other. Following Don Peppone's sudden death, the two capos divided their Don's empire and each governed their own territory. Despite their good relationship, Salieri and Morello gradually fell out, leading to a 'cold war' of sorts. Morello would antagonise Salieri, albeit never attempting an outright war with him.
Don Salieri is calculating and generous, willing to help families and friends in need and ensures that his neighborhood is protected from both delinquents and Morello's gang. He is also gifted with the ability to think long-term, noting how the end of Prohibition will force him to venture into new avenues of income, both legal and illegal. He values loyalty above everything but still retains some measure of strictness, ensuring that his subordinates do not get complacent or negligent in their financial ventures.
Despite this, Salieri has a darker side, a vengeful anger whenever he is deeply hurt, be it emotionally or financially. Frank Colletti recalls to Tommy Angelo when Colletti's race dog lost for the first time and Salieri attempted to drown it, resorting to shooting it after being stopped by Colletti. He keeps this largely under control but seems to lose control more often after Frank Colletti's departure from the Salieri Crime Family. Following the attempt on his life by Morello, Salieri lashes out at Carlo for betraying him, demonstrating the extent and fury Salieri can have under adverse circumstances.
By the end of the game, Salieri is shown to be sentenced to life in prison, after Tommy decided to testify against the Salieri family in court, in exchange for his shorter sentence and his family's guaranteed safety. Despite Salieri's imprisonment, his anger at Tommy's betrayal motivates him to seek out allies in the Empire Bay crime families. In 1951, Salieri finally exacts revenge on Tommy Angelo through the Falcone Crime Family, Falcone soldatos Vito Scaletta and Joe Barbaro carrying out the hit on Don Salieri's behalf.
- Carlo (soldato, Salieri Crime Family)
- Molotov Party
- Ordinary Routine
- Fair Play
- Better Get Used to It
- The Saint and the Sinner
- A Trip to the Country
- Visiting Rich People
- Great Deal
- Bon Appétit
- Happy Birthday
- You Lucky Bastard
- Crème de la Crème
- Election Campaign
- Just for Relaxation
- Epilogue (arrested)
- Salieri was the best man at Morello’s wedding in 1920.
- Salieri is a friend of the Vinci Crime Family's Don Frank Vinci.
- Glenn Taranto, his voice actor, also portrays Earl Wilson in Mafia III.